Biotechnology: A Comprehensive Overview of Its Evolution and Applications
Biotechnology: A Comprehensive Overview of Its Evolution and Applications
Keywords:
Fermentación, Ingeniería Genética, Organismo genéticamente modificadoAbstract
This work presents a comprehensive overview of the historical evolution and contemporary applications of biotechnology, emphasizing its interdisciplinary nature and impact across multiple key sectors. It explores the empirical origins of the field, from ancient practices to current innovations such as gene editing through CRISPR-Cas9 and the integration of artificial intelligence in biotechnological processes. A chromatic classification is proposed to distinguish the various branches of biotechnology based on their fields of application: red (human health), green (agriculture), white (industrial), grey (environmental), blue (marine), yellow (food), gold (bioinformatics), violet (ethics and biosafety), brown (arid ecosystems), black (bioterrorism), and orange (education and outreach). This taxonomy enhances the understanding of biotechnology’s scope and fosters critical analysis of its scientific, social, and ethical implications. The manuscript also addresses challenges related to its development and adoption, including bioethical controversies, regulatory frameworks, and cultural variations in public acceptance. It highlights the fundamental role of biotechnology in tackling global challenges such as climate change, food security, public health, and environmental sustainability, aligning with the Sustainable Development Goals. Altogether, the document serves as a valuable reference for researchers, educators, and professionals seeking to understand the breadth, depth, and global impact of biotechnology in the modern era.
References
Acosta Murillo, R., y Castañon Baltazar, J. C. (2022). Las tendencias, perspectivas, áreas y colores de la biotecnología. Revista Digital Universitaria, 23(4). https://doi.org/10.22201/cuaieed.16076079e.2022.23.4.10
Andrade, G., Alcántara, H., González, M., Silva, R., Vilchis Landeros, L., Tonatiuh, V., Silvia, L., y Estela, R. (2021). Uso del sistema CRISPR-Cas9 para la edición de genes en organismos modelo y líneas celulares. Mensaje Bioquímico, 45, 134–156. http://bq.facmed.unam.mx/tab
Anestopoulos, I., Kiousi, D. E., Klavaris, A., Maijo, M., Serpico, A., Suarez, A., Sanchez, G., Salek, K., Chasapi, S. A., Zompra, A. A., Galanis, A., Spyroulias, G. A., Gombau, L., Euston, S. R., Pappa, A., y Panayiotidis, M. I. (2020). Marine‐derived surface-active agents: Health‐ promoting properties and blue biotechnology‐based applications. In Biomolecules, 10(6), 1–27. https://doi.org/10.3390/biom10060885
Arana-Cuenca, A., Ransanz Reyes, E., Curto Prieto, M., y Romero-García. (2022). Biotecnología por colores: Impacto en el rendimiento académico del alumnado de educación secundaria. En C. Romero García (Ed.), Innovación docente y prácticas educativas para una educación de calidad. Dykinson, S.L.
Augustin, M. A., Hartley, C. J., Maloney, G., y Tyndall, S. (2024). Innovation in precision fermentation for food ingredients. En Critical Reviews in Food Science and Nutrition,64(18), 6218–6238. https://doi.org/10.1080/10408398.2023.2166014
Barcelos, M. C. S., Lupki, F. B., Campolina, G. A., Nelson, D. L., y Molina, G. (2018). The colors of biotechnology: General overview and developments of white, green and blue areas. FEMS Microbiology Letters, 365(21). https://doi.org/10.1093/femsle/fny239
Cabrera-Barjas, G., Banerjee, A., Valdes, O., Moncada, M., Sirajunnisa, A. R., Surendhiran, D., Ramakrishnan, G., Rani, N. S., Hamidi, M., Kozani, P. S., Kozani, P. S., Espitia, P. J. P., Fuenmayor, C. A., Pierre, G., Michaud, P., Lukova, P., y Delattre, C. (2021). Food biotechnology: Innovations and challenges. En Future Foods: Global Trends, Opportunities, and Sustainability Challenges. https://doi.org/10.1016/B978-0-323-91001-9.00038-4
Casas, A., Parra, F., Blancas Vázquez, J., Rangel-Landa, S., Vallejo, M., Figueredo, C. J., y Moreno-Calles, A. I. (2016). Origen de la domesticación y la agricultura: cómo y por qué. En UNAM-UNALM (Ed.), Domesticación en el Continente Americano. https://www.researchgate.net/publication/314090020
Chazhaev, M. (2023). The current state of the biotechnology market and its main development trends. BIO Web of Conferences, 76, 09009. https://doi.org/10.1051/bioconf/20237609009
da Silva Campos, M., Batista de Sousa, F. J., Martins, F. J., & Castro, H. C. (2021). Dark Biotechnology: Reminding the Imminent Threats for World Largest Food Producers During COVID-19 Pandemic Situation. Advances in Biotechnology & Microbiology, 16(3), 27–35. https://doi.org/10.19080/aibm.2021.16.555939
DaSilva, E. J. (2004). The Colours of Biotechnology: Science, Development and Humankind. Electronic Journal of Biotechnology, 7(3), 1–2.
Ereky, K. (1919). Biotechnologie der Fleisch-, Fett-, und Milcherzeugung im landwirtschaftlichen Grossbetriebe: für naturwissenschaftlich gebildete Landwirte verfasst. P. Parey.
Escamilla Hurtado, M. de L., y Escamilla Hurtado, M. G. (2007). Los alimentos fermentados que comían nuestros bisabuelos prehispánicos. Ciencia, 75.
Gauthier, J., Vincent, A. T., Charette, S. J., y Derome, N. (2019). A brief history of bioinformatics. Briefings in Bioinformatics, 20(6), 1981–1996. https://doi.org/10.1093/bib/bby063
Gutierrez Reyes, C. D., Alejo-Jacuinde, G., Perez Sanchez, B., Chavez Reyes, J., Onigbinde, S., Mogut, D., Hernández-Jasso, I., Calderón-Vallejo, D., Quintanar, J. L., y Mechref, Y. (2024). Multi Omics Applications in Biological Systems. In Current Issues in Molecular Biology, 46(6), 5777–5793. https://doi.org/10.3390/cimb46060345
Holzinger, A., Keiblinger, K., Holub, P., Zatloukal, K., y Müller, H. (2023). AI for life: Trends in artificial intelligence for biotechnology. New Biotechnology, 74, 16–24. https://doi.org/10.1016/j.nbt.2023.02.001
Iannizzi, C., Chai, K. L., Piechotta, V., Valk, S. J., Kimber, C., Monsef, I., Wood, E. M., Lamikanra, A. A., Roberts, D. J., McQuilten, Z., So-Osman, C., Jindal, A., Estcourt, L. J., Kreuzberger, N., y Skoetz, N. (2023). Convalescent plasma for people with COVID-19: a living systematic review. Cochrane Database of Systematic Reviews, 2024(2). https://doi.org/10.1002/14651858.cd013600.pub6
Jácome Pilco, C., Alucho Quinaloa, M., Muyulema Cuvi, E., Tulmo Negrete, E., y García Muñoz, M. (2023). Alimentos transgénicos: sus beneficios para la nutrición en América Latina y el Caribe. LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades, 4(1). https://doi.org/10.56712/latam.v4i1.354
Javier Díaz-Castrillón, F., & Toro-Montoya, A. I. (2020). SARS-CoV-2/COVID-19: el virus, la enfermedad y la pandemia. Medicina & Laboratorio, 24(3), 183–205. https://doi.org/10.1007/978-3-642-14995-5
Kafarski, P. (2012). Rainbow code of biotechnology. Chemik, 8. http://pl.wikipedia.org/wiki/Biotechnologia
Knäblein, J. (2013). Twenty Thousand Years of Biotech - From “Traditional” to “Modern Biotechnology.” En Modern Biopharmaceuticals: Recent Success Stories (pp. 1–38). https://doi.org/10.1002/9783527669417.ch1
Kordi, M., Salami, R., Bolouri, P., Delangiz, N., Asgari Lajayer, B., y van Hullebusch, E. D. (2022). White biotechnology and the production of bio-products. Systems Microbiology and Biomanufacturing, 2(3), 413–429. https://doi.org/10.1007/s43393-022-00078-8
Li, Z., Ji, X., Kan, suli, Qiao, H., Jiang, M., Lu, D., Wang, J., Huang, H., Jia, H., Ouyuang, P., y Ying, H. (2010). Past, Present, and Future Industrial Biotechnology in China. En G. T. Tsao, P. Ouyang, J. Chen (Eds.), Biotechnologu in China II: Chemicals, Energy and Environment. Springer Heidelberg Dordrecht London New York. https://doi.org/10.1007/978-3-642-14995-5
López Puc, G., Cano Sosa, J. del S., Ramos Díaz, A., y Uc-Váguez, A. (2021). Biotecnología Vegetal: Conceptos, técnicas y herramientas. En J. del S. Cano Sosa & G. López Puc (Eds.). Alcances y perspectivas del área de Biotecnología Vegetal del CIATEJ en el Sureste de México. Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C.
López-Muñoz, F., Salas-Moreno, P., Montero-Sánchez, M., De-la-Puente-Mora-Figueroa, I., Suárez-Muñoz, A., García-Crespín, J., y Díaz-Muñoz, F. (2021). Amenazas biológicas intencionadas: implicaciones para la Seguridad Nacional. Sanidad Militar, 77(2), 98–105. https://doi.org/10.4321/s1887-85712021000200006
Mayans, C. (2023). Historia National Geographic. Frutas, Pan, Cerveza... La Producción de Alimentos En El Antiguo Egipto. https://historia.nationalgeographic.com.es/a/carnes-frutas-verduras-pan-cerveza-la-produccion-de-alimentos-en-el-antiguo-egipto_19480
Ortega-Ante, D. A. (2020). Enfoque de la Biotecnología Industrial en Ecuador y la Provincia de Esmeraldas. Polo Del Conocimiento, 5(8), 1228–1239. https://doi.org/10.23857/pc.v5i8.1655
Padrón López, R. M., Hernández Marín, A., y Lesher Gordillo, J. M. (2022). Historia y aplicaciones de la reacción en cadena de la polimerasa en el diagnóstico clínico. Kuxulkab, 28(61), 23–32. https://doi.org/10.19136/kuxulkab.a28n61.4593
Pande, A., y J., A. (2024). Dark Biotechnology -An Emerging Solution To CBRN Emergencies. The Defence Horizon Journal. https://doi.org/10.5281/zenodo.10701826
Prabha, S. P., Nagappan, S., Rathna, R., Viveka, R., y Nakkeeran, E. (2019). Blue biotechnology: A vision for future marine biorefineries. En Refining Biomass Residues for Sustainable Energy and Bioproducts: Technology, Advances, Life Cycle Assessment, and Economics (pp. 463–480). Elsevier. https://doi.org/10.1016/B978-0-12-818996-2.00021-1
Renneberg, R. (2019). Biotecnología para principiantes (R. Renneberg, Ed.). Editorial Reverté.
Rodríguez-Núñez, K., Rodríguez-Ramos, F., Leiva-Portilla, D., y Ibáñez, C. (2020). Brown biotechnology: a powerful toolbox for resolving current and future challenges in the development of arid lands. SN Applied Sciences, 2(7), 1187. https://doi.org/10.1007/s42452-020-2980-0
Roy, I., y Gupta, M. N. (2023). White y grey biotechnologies for shaping a sustainable future. RSC Sustainability, 66. https://doi.org/10.1039/d3su00174a
Sadeghalvad, M., y Rezaei, N. (2021). Introduction on Monoclonal Antibodies. En Monoclonal Antibodies. https://doi.org/10.5772/intechopen.98378
Singh, A. K., y Jain, B. (2024). Bionanotechnology for Advanced Applications. CRC Press. https://doi.org/10.1201/9781003362258
Smith, J. E. (2009). Biotechnology (5ed.). Cambridge Univ Pr.
Soumia, B., Rofia, A., y Nadia, Y. (2023). Biotechnology: definitions, types and main applications. YMER Digital, 22(4), 563–575. https://doi.org/10.37896/YMER22.04/49
Srivastava, P., y Garg, P. (2024). Omics Applications and Avenues. Cambridge Scholars Publishing.
Vargas, M. R., Melendrez-Arango, E. C., Durán-Aguirre, M. L., Quiñones Lucero, L., y Peralta-Peña, S. L. (2021). Tratamiento farmacológico en pacientes con COVID-19: una revisión integradora. SANUS, 6, e250. https://doi.org/10.36789/revsanus.vi1.250
Villacreses Soledispa, D. J., Bermúdez Rodríguez, A. N., Campozano Pilay, Y. H., y Álvarez Márquez, N. del C. (2022). La biotecnología y su impacto con el uso de las tecnologías. Journal TechInnovation, 1(2), 78–87. https://doi.org/10.47230/journal.techinnovation.v1.n2.2022.78-87
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Maria Guadalupe Rodriguez Vidarte, Essa Emiret Pacheco Reyes, Martha Catalina Bernal Ramírez, Mariana Díaz-Zaragoza, Omar Graciano-Machuca

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.