Papel de las células supresoras de origen mieloide y Arginasa-1 en cáncer de endometrio
Role of Myeloid-Derived Suppressor Cells and Arginase-1 in Endometrial Cancer
Palabras clave:
Cánce ginecológico, sistema inmune, células inmunes inmaduras, desarrollo del cáncerResumen
El cáncer de endometrio es el cuarto cáncer ginecológico más frecuente a nivel mundial, mientras que en México se posiciona en el quinto lugar. En los últimos años, se ha asociado el porcentaje de células supresoras de origen mieloide (MDSCs) y las concentraciones séricas de Arginasa-1 con un peor pronóstico para los pacientes con cáncer. Las MDSCs son células inmunitarias inmaduras, producidas por una mielopoyesis alterada. Presentan características fenotípicas y morfológicas inmaduras, así como funciones antiinflamatorias e inmunosupresoras que pueden promover el crecimiento tumoral en comparación con sus homólogas maduras. Las MDSCs producen diversas moléculas, incluyendo la arginasa-1, enzima que desempeña un papel en el ciclo de la urea y otros procesos celulares. En el cáncer, la Arginasa-1 puede suprimir la función de las células T y las células natural killer (NK), lo que también contribuye a la evasión inmune de las células tumorales. Además de ayudar a promover la actividad de las MDSCs. En este artículo se describen aspectos relevantes de las células supresoras de origen mieloide y la Arginasa-1, así como su papel en el desarrollo del cáncer de endometrio.
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Derechos de autor 2025 Grecia Camila Pérez Cárdenas, Fabiola Solórzano Ibarra, Martha Cecilia Téllez Bañuelos, Brenda Guadalupe Ortiz Tamayo, Pablo Cesar Ortiz Lazareno
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
