Experimental models of epilpesy to identify the physiopathology and evaluate new anticonvulsant

Abstract

Epilepsy is a neurological alteration which has a prevalence from 2 to 5% and approximately 67 million people in the world suffer it. One of the most drug resistant epilepsy is the temporal lobe epilepsy (ELT). During some years has occurred the increase in the comprehension in advances about the crisis, of the epilepsy and epileptogenic mechanism, this would not have been imagined 30 years ago. This progress comes from a long list of studies of the system of animal models that try to rebuild many of the specific details that control both the inhibition as the excitation that give pla- ce to the seizures in different regions of the brain either cortical or subcortical.
The use of animal models plays a very im- portant role for the modern biomedical investi- gation, the development of these different mo- dels may reproduce especial characteristics for clinic syndromes, phenotypes and different brain damages, that for a long time have been an im- portant aspect of the investigation in the epilepsy in this work we will try some of the acute and chro- nic models use to generate seizures through the application of drugs such as: 4-aminopyridine (4-AP), pilocarpine (PILO) and kainic acid (AK) though different administration ways, these are some of the most used models in the laboratory.