Acute and chronic neurodegeneration a continuum in the establishment of neurodegenerative disorders

Abstract

As worldwide human population grows in number and gets older, disabilities derived from neurological disorders become more present. In addition to the lack of efforts directed to preventive actions against the occurrence and establishment of a neurological disorder, will lead governmental institutions to face an increasing requirement for treatment and rehabilitations programs to deal with consequences caused by these disorders. Demonstrating the importance that neuroscientists focus on the design of new paradigms that allow the identification of a potential prophylactic and therapeutic treatment for these disorders, is a key step. In the present work, authors did an overall bibliographical review and general description of the mechanisms involved on acute and chronic neurodegenerative damage, trying to show the common points on both kind of damage. Therefore, to identify and substantiate the key characteristics that link degenerative progression from an acute damage to the establishment of a chronical neurological disorder. Highlighting the value of early interventions on acute neurological damage, centered on neuroprotection via cell signaling pathways that could mediate or prevent neuronal damage. Consequently, to spot and notice the repercussions and transcendence that research in therapeutic strategies focus on mimic and potentiate the compensatory response unchained after a neurological damage, is a key factor to find new treatments for these disorders.