ANTIMICROBIAL ACTIVITY PRESENT IN Ganoderma curtisii AQUEOUS EXTRACTS

Resumen

Macroscopic mushrooms have proven to be excellent sources of protein. In addition to this, their medicinal properties have been noted, including their natural antitumor, antiviral, antimicrobial, and antioxidant action, as well as their role in immune system modulation. Although polysaccharides and triterpenoids have been identified as the main antimicrobial components of the Ganoderma species, some studies mention peptidic components that possess antimicrobial effects such as ganodermin, a 15-kDa antifungal peptide. In view of the growing demand for molecules with potential therapeutic applications that could help fight antibiotic-resistant microorganisms, the purpose of this work consists of studying the antimicrobial activity of aqueous extracts of Ganoderma curtisii, found in “La Primavera” Forest in Jalisco, Mexico. The aqueous extracts of G. curtisii showed specific dose-response antibacterial activity against E. coli. Furthermore, PAGE-SDS gels obtained from the pileus of the G. curtisii aqueous extracts show peptide bands measuring approximately 5 kDa, along with bands measuring between 10 and 15 kDa, which could represent the antimicrobial peptides that completely inhibited the growth of E. coli when the conventional CFU microdilution method was used. A preliminary conclusion is that the findings reported in this study can be seen as potentially useful and original for therapeutic application in the field of biomedicine.