Main Etiological Agents of Bovine Mastitis
Main Etiological Agents of Bovine Mastitis
Keywords:
Staphylococcus aureus, Streptococcus spp, antimicrobial resistance, virulence factors, biofilms, dairy cattle, animal welfareAbstract
Bovine mastitis is an inflammatory disease of the mammary gland with major economic, sanitary and welfare implications in dairy production. It is caused mainly by bacterial pathogens such as Staphylococcus aureus, Streptococcus agalactiae, Streptococcus uberis and Escherichia coli, which differ in their epidemiology, virulence mechanisms and antimicrobial resistance profiles. This article presents a comparative analysis of the principal etiological agents of bovine mastitis, highlighting their prevalence, transmission patterns and capacity to persist within the mammary gland through mechanisms such as biofilm formation and immune evasion. Special attention is given to the increasing problem of antimicrobial resistance and its impact on treatment efficacy. In addition, recent advances in molecular diagnostics, biotechnological tools and alternative therapeutic strategies are discussed as key components for improving mastitis control, animal welfare and sustainable dairy production within a One Health framework.
References
Abebe, R., H. Hatiya, M. Abera, B. Megersa & K. Asmare. (2016). Bovine mastitis: Prevalence, risk factors and isolation of Staphylococcus aureus in dairy herds at Hawassa milk shed, South Ethiopia. BMC Veterinary Research, 12(1), 270. https://doi.org/10.1186/s12917-016-0905-3
Abureema, S., P. Smooker, J. Malmo & M. Deighton. (2014). Molecular epidemiology of recurrent clinical mastitis due to Streptococcus uberis: Evidence of both an environmental source and recurring infection with the same strain. Journal of Dairy Science, 97(1), 285–290. https://doi.org/10.3168/jds.2013-7074
Ali, T., S. Rahman, L. Zhang, M. Shahid, D. Han, J. Gao & et al. (2021). Prevalence and antibiotic susceptibility of mastitis pathogens in Pakistan. Frontiers in Veterinary Science, 8, 746755. https://doi.org/10.3389/fvets.2021.746755
Bari, M.S., M.A. Islam, M. Uddin, B.C. Das, A. Khatun, M.M. Rahman & et al. (2023). Advances in therapeutic and managemental approaches of bovine mastitis: A comprehensive review. Veterinary World, 16(5), 1132–1148. https://doi.org/10.14202/vetworld.2023.1132-1148
Bonifaz, M., J. Conlago & A. Cabrera. (2024). Etiología bacteriana de mastitis bovina en Ecuador. Pesquisa Veterinaria, 41(1), 12–20.
Bonifaz, M. & J, Conlago. (2016). Caracterización bacteriológica de mastitis subclínica en ganado lechero. Revista Latinoamericana de Veterinaria, 25(2), 88–95.
Bludau, M.J., A. Maeschli, F. Leiber, A. Steiner & P. Klocke. (2014). Mastitis in dairy heifers: Prevalence and risk factors. The Veterinary Journal, 202(3), 566–572. https://doi.org/10.1016/j.tvjl.2014.09.021
Bradley, A.J., K.A. Leach, J.E. Breen, L.E. Green & M.J. Green. (2022). Antimicrobial resistance of Streptococcus uberis. CABI Digital Library. https://doi.org/10.5555/20230459132
Campos, B., A.C. Pickering, L.S. Rocha, A.P. Aguilar, M.H. Fabres-Klein, T.A.O. Mendes & et al. (2022). Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: Current understanding and future perspectives. BMC Veterinary Research, 18(115). https://doi.org/10.1186/s12917-022-03197-5
Cardozo, V.F., C.A. Lancheros, A.M. Narciso, E.C. Valereto, R.K. Kobayashi, A.B. Seabra & G. Nakazato. (2014). Evaluation of antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus and Escherichia coli from bovine mastitis. International Journal of Pharmaceutics, 473(1–2), 20–29. https://doi.org/10.1016/j.ijpharm.2014.06.051
Cruz, L., H. Torres & D. Jaramillo. (2007). Frecuencia de mastitis subclínica en ganado lechero. Revista Producción Animal, 19(2), 87–94.
Dogan, B., S. Klaessig, M. Rishniw, R.A. Almeida, S.P. Oliver, K. Simpson & et al. (2025). Escherichia coli from bovine mastitis: Virulence and antimicrobial resistance. Journal of Dairy Science, 108(3), 2156–2174. https://doi.org/10.3168/jds.2024-22614
Gomes, F. & M. Henriques. (2023). Virulence of bacteria causing mastitis in dairy cows. Microorganisms, 13(1), 167. https://doi.org/10.3390/microorganisms13010167
Kabelitz, T., E. Aubry, K. van Vorst, T. Amon & M. Fulde. (2021). The role of Streptococcus spp. in bovine mastitis. Microorganisms, 9(7), 1497. https://doi.org/10.3390/microorganisms9071497
Kamel, M., A. El-Sayed & H. Castañeda Vázquez. (2019). Foot-and-mouth disease vaccines: Recent updates and future perspectives. Archives of Virology. 164(6): 1501–1513. https://doi.org/10.1007/s00705-019-04216-x
Keefe, G. (2019). Epidemiology and classification of mastitis. Animals, 10(12):, 2212. https://doi.org/10.3390/ani10122212
Mahmud, Z.H., M. Moniruzzaman, M.T. Hussain, M. Hossain, M.A. Ul Alam, M.S. Hossain y col. (2023). Characteristics of ESBL-producing Escherichia coli from hospital environments and clinical samples in Bangladesh. Heliyon, 9, e22109. https://doi.org/10.1016/j.heliyon.2023.e22109
Maity, S. & K. Ambatipudi. (2021). Mammary microbial dysbiosis leads to the zoonosis of bovine mastitis: A One-Health perspective. FEMS Microbiology Ecology, 97(1), fiaa241. https://doi.org/10.1093/femsec/fiaa241
Miotti, C., J. Cicotello, G.A. Suarez Archilla, V. Neder, W.A. Alvarado Lucero, L. Calvinho, M.L. Signorini Porchietto, C.M. Camussone, M.V. Zbrun, A.I. Molineri & et al. (2023). Antimicrobial resistance of Streptococcus uberis isolated from bovine mastitis: Systematic review and meta-analysis. Research in Veterinary Science, 164, 105032. https://doi.org/10.1016/j.rvsc.2023.105032
Morales-Ubaldo, A.L., N. Rivero-Pérez, B. Valladares-Carranza, V. Velázquez-Ordóñez, L. Delgadillo-Ruiz & A. Zaragoza-Bastida. (2023). Bovine mastitis, a worldwide impact disease: Prevalence, antimicrobial resistance, and viable alternative approaches. Veterinary and Animal Science, 21, 100306. https://doi.org/10.1016/j.vas.2023.100306
Moroni, P., C. Sgoifo Rossi, G. Pisoni, V. Bronzo, B. Castiglioni & P. Boettcher. (2022). Etiological agents and bacterial sensitivity in subclinical mastitis. Veterinaria Italiana, 58(1), 45–52.
Oliver, S.P. & S.E. Murinda. (2022). Antimicrobial resistance in bovine mastitis pathogens: A review. Journal of Dairy Science, 105(5), 3927–3941. https://doi.org/10.3168/jds.2021-21347
Ruegg, P.L. (2022). Combating bovine mastitis in the dairy sector. Frontiers in Veterinary Science, 9, 800322. https://doi.org/10.3389/fvets.2022.800322
Sabino, Y.N.V., P.D. Cotter & H.C. Mantovani. (2023). Anti-virulence compounds against Staphylococcus aureus associated with bovine mastitis: A new therapeutic option? Microbiological Research, 271, 127345. https://doi.org/10.1016/j.micres.2023.127345
Sharma, N., N.K. Singh & M.S. Bhadwal. (2017). Mastitis pathogens in dairy cattle – A review. Journal of Animal Research, 7(6), 1133–1147. https://www.researchgate.net/publication/320455540. [consultado 03 febrero 2026].
Wolter, W., V.H. Castañeda, B. Kloppert & M. Zschöck. (1999). La mastitis bovina. Instituto Estatal de Investigaciones de Hesse y Universidad de Guadalajara, Wiesbaden, Alemania.
Zigo, F., M. Vasil, S. Ondrašovičová, J. Výrostková, J. Bujok & E. Pecka-Kielb. (2023). Pathogens associated with bovine mastitis: The experience of European dairy herds. Veterinary Sciences, 10(2), 63. https://doi.org/10.3390/vetsci10020063
Zouharova, M., K. Nedbalcova, P. Slama, J. Bzdil, M. Masarikova & J. Matiasovic. (2022). Occurrence of virulence-associated genes in Streptococcus uberis and Streptococcus parauberis isolated from bovine mastitis. Veterinary Medicine (Czech), 67, 123–130. https://doi.org/10.17221/95/2021-VETMED
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Melany Isabel Landeros Aceves, Hugo Castañeda Vázquez

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.



