miRNAs as regulatory molecules in cancer

miRNAs as regulatory molecules in cancer

Authors

  • Gabriela Sarai Navarro-Parga Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud.
  • Martha Cecilia Téllez Bañuelos Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias.
  • Fabiola Solórzano Ibarra Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud.
  • Yail Patricia Gómez Medel Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud.
  • Pablo Cesar Ortiz Lazareno Instituto Mexicano del Seguro Social. Centro de Investigación Biomédica de Occidente.

Keywords:

RNA, biogenesis, oncogene, biomarkers

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play a fundamental role in post-transcriptional gene regulation, participating in key biological processes such as cell proliferation, differentiation, and metabolism. Their biogenesis involves highly regulated mechanisms, whose alteration has been associated with the development of various pathologies, including cancer. In the tumor context, miRNAs can act as oncogenes or tumor suppressors, influencing fundamental characteristics such as proliferative signaling, evasion of growth suppressors, resistance to cell death, and metastasis. This review examines the molecular mechanisms that regulate the synthesis and function of miRNAs, as well as their involvement in oncogenic processes. In addition, it discusses their use as biomarkers and therapeutic targets, highlighting both the advantages and current challenges in their clinical implementation.

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Published

2026-01-01

How to Cite

Navarro-Parga, G. S., Téllez Bañuelos, M. C., Solórzano Ibarra, F., Gómez Medel, Y. P., & Ortiz Lazareno, P. C. (2026). miRNAs as regulatory molecules in cancer: miRNAs as regulatory molecules in cancer. E-CUCBA, (27), 31–39. Retrieved from http://e-cucba.cucba.udg.mx/index.php/e-Cucba/article/view/415

Issue

No. 27 (13): e-CUCBA | January - April 2026

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Artículos

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Copyright (c) 2025 Gabriela Sarai Navarro-Parga, Martha Cecilia Tellez Bañuelos, Fabiola Solorzano Ibarra, Yail Patricia Gómez Medel, Pablo Cesar Ortiz Lazareno

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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